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The AND-PD project aims to improve the diagnosis, management and treatment of anxiety as a co-morbidity of Parkinson's disease (PD) through greater understanding of its neurobiological causes

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Objectives

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There are 10 work packages in the AND-PD project

1

1

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Defining the phenotype of comorbid anxiety/depression in PD animal models  

2

2

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 Defining the neural circuitry that underlies comorbidity 

3

3

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Disruption of neural circuitry to cause co-morbidity

4

4

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Rescue co-morbidities with novel RNA based neuroprotection and circuit interventions in the mid-brain that restore the functional role of specific neurons. 

5

5

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Molecular characterisation of PD co-morbidities

6

6

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Linking mid-brain degeneration with anxiety/depression symptoms in post-mortem PD brain samples 

7

7

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Mid-brain functional connectivity in PD patients

8

8

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Clinical phenotyping and risk factors of comorbidities in patients 

9

9

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Dissemination and Exploitation 

10

10

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Consortium Management and Governance 

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